Difference between revisions of "Performance of objective functions and optimization procedures for parameter estimation in system biology models"
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Employing data-driven normalization instead of scaling factors improved the identifiability of dynamic parameters, providing a computational example to demonstrate how this occurs. | Employing data-driven normalization instead of scaling factors improved the identifiability of dynamic parameters, providing a computational example to demonstrate how this occurs. | ||
| − | ==== | + | ==== Convergence Speed ==== |
| − | .. | + | As visualized in Fig. 4 and Fig. 5 of the original publication, convergence speed was consistently improved using data driven normalization compared to scaling factors. Combining the data-driven normalization with the hybrid optimization algorithm GLSDC provided the best performance results especially in high-parameter settings. |
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=== Study design and evidence level === | === Study design and evidence level === | ||
==== General aspects ==== | ==== General aspects ==== | ||
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| − | The study | + | * Although the previously best-performing method using LSQNONLIN with sensitivity equations as found in [[Lessons Learned from Quantitative Dynamical Modeling in Systems Biology]] has been mentioned, but a comparison with GLSDC was restricted to use of their implementations of it. |
| + | * The study used Least-Squares instead of Likelihood as objective function, omitting error model fits. | ||
==== Design for Outcome O1 ==== | ==== Design for Outcome O1 ==== | ||
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=== Further comments and aspects === | === Further comments and aspects === | ||
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| + | * Additionally to the performance advantages of not using scaling factors, it is also stated that the amount of overfitting is reduced. | ||
=== References === | === References === | ||
The list of cited or related literature is placed here. | The list of cited or related literature is placed here. | ||
Revision as of 13:10, 25 February 2020
Contents
1 Citation
Andrea Degasperi, Dirk Fey & Boris N. Kholodenko, Performance of objective functions and optimisation procedures for parameter estimation in system biology models, 2017, Systems Biology and Applications volume 3, Article number: 20
2 Summary
In systems biology, relative data are a common occurrence. In ODE-based models, this is regarded by either introducing scaling parameters or data-driven normalization to bring data and simulations onto the same scale. It was shown in this article, that data-driven normalization improves optimization performance and does not aggravate non-identifiability problems compared to a scaling factor approach. Furthermore, this article reports that hybrid optimization methods which combine stochastic global and deterministic local search outperforms deterministic local gradient-based strategies.
3 Study outcomes
The provided claims are tested on 3 parameter estimation problems.
3.1 Identifiability
Employing data-driven normalization instead of scaling factors improved the identifiability of dynamic parameters, providing a computational example to demonstrate how this occurs.
3.2 Convergence Speed
As visualized in Fig. 4 and Fig. 5 of the original publication, convergence speed was consistently improved using data driven normalization compared to scaling factors. Combining the data-driven normalization with the hybrid optimization algorithm GLSDC provided the best performance results especially in high-parameter settings.
4 Study design and evidence level
4.1 General aspects
- Although the previously best-performing method using LSQNONLIN with sensitivity equations as found in Lessons Learned from Quantitative Dynamical Modeling in Systems Biology has been mentioned, but a comparison with GLSDC was restricted to use of their implementations of it.
- The study used Least-Squares instead of Likelihood as objective function, omitting error model fits.
4.2 Design for Outcome O1
- The outcome was generated for ...
- Configuration parameters were chosen ...
- ...
4.3 Design for Outcome O2
- The outcome was generated for ...
- Configuration parameters were chosen ...
- ...
...
4.4 Design for Outcome O
- The outcome was generated for ...
- Configuration parameters were chosen ...
- ...
5 Further comments and aspects
- Additionally to the performance advantages of not using scaling factors, it is also stated that the amount of overfitting is reduced.
6 References
The list of cited or related literature is placed here.
